Poor outcome in steroid-refractory graft-versus-host disease with antithymocyte globulin treatment
S Arai, J Margolis, M Zahurak, V Anders… - Biology of Blood and …, 2002 - tctjournal.org
Abstract Treatment of acute graft-versus-host disease (aGVHD) has relied on high-dose
steroids, but less than 50% of patients show durable remission. Antithymocyte globulin
(ATG) has become a standard salvage therapy. We now report our experience with ATG for
the treatment of steroid-refractory GVHD in 69 patients treated from January 1, 1980, to May
1, 1999. Patients with GVHD were given an overall grade using standard criteria. Overall
responses were similar to those in previously published literature. However, long-term …
steroids, but less than 50% of patients show durable remission. Antithymocyte globulin
(ATG) has become a standard salvage therapy. We now report our experience with ATG for
the treatment of steroid-refractory GVHD in 69 patients treated from January 1, 1980, to May
1, 1999. Patients with GVHD were given an overall grade using standard criteria. Overall
responses were similar to those in previously published literature. However, long-term …