Insulin action in the normal and polycystic ovary
S Franks, C Gilling-Smith, H Watson, D Willis - … and metabolism clinics of …, 1999 - Elsevier
Polycystic ovary syndrome (PCOS) is the most common cause of anovulatory infertility and
hirsutism. 1, 22 In addition to the reproductive consequences of the syndrome, PCOS is
characterized by a metabolic disorder in which hyperinsulinemia and peripheral insulin
resistance are central features. 9, 21 The characteristic disturbances of insulin secretion and
action are much more prominent in women with PCOS with amenorrhea or anovulatory
menses than in equally hyperandrogenemic women with regular cycles. 7, 37 These …
hirsutism. 1, 22 In addition to the reproductive consequences of the syndrome, PCOS is
characterized by a metabolic disorder in which hyperinsulinemia and peripheral insulin
resistance are central features. 9, 21 The characteristic disturbances of insulin secretion and
action are much more prominent in women with PCOS with amenorrhea or anovulatory
menses than in equally hyperandrogenemic women with regular cycles. 7, 37 These …