[HTML][HTML] Platelet-derived growth factor-DD targeting arrests pathological angiogenesis by modulating glycogen synthase kinase-3β phosphorylation

A Kumar, X Hou, C Lee, Y Li, A Maminishkis… - Journal of biological …, 2010 - ASBMB
Platelet-derived growth factor-DD (PDGF-DD) is a recently discovered member of the PDGF
family. The role of PDGF-DD in pathological angiogenesis and the underlying cellular and
molecular mechanisms remain largely unexplored. In this study, using different animal
models, we showed that PDGF-DD expression was up-regulated during pathological
angiogenesis, and inhibition of PDGF-DD suppressed both choroidal and retinal
neovascularization. We also demonstrated a novel mechanism mediating the function of …