Genetics and pharmacogenetics of the leukotriene pathway

KG Tantisira, JM Drazen - Journal of Allergy and Clinical Immunology, 2009 - Elsevier
Leukotrienes are now established contributors to the inflammatory process in asthma, and
leukotriene modifiers are mainstays in the therapy of asthma. This review focuses on
published association studies implicating the role of leukotriene pathway genes in asthma
pathogenesis and treatment response, specifically focusing on those genetic variants
associated with asthma affection status, the development of aspirin-exacerbated respiratory
disease, and pharmacogenetic response. Although published studies have been limited by …