From phenotypes to endotypes to asthma treatment
IO Agache - Current opinion in allergy and clinical immunology, 2013 - journals.lww.com
Current opinion in allergy and clinical immunology, 2013•journals.lww.com
Each of the hallmark characteristics of asthma (inflammation, remodeling, airway
hyperreactivity) is the expression of a complex network of molecules, very diverse both
within any given patient in time and between any two patients. Some of these networks are
repetitive across individuals with asthma and specific for clinical expression, gene–
environment interaction and inflammatory cell profiles represent novel endotype-specific
diagnostic and therapeutic strategies.
hyperreactivity) is the expression of a complex network of molecules, very diverse both
within any given patient in time and between any two patients. Some of these networks are
repetitive across individuals with asthma and specific for clinical expression, gene–
environment interaction and inflammatory cell profiles represent novel endotype-specific
diagnostic and therapeutic strategies.
Summary
Each of the hallmark characteristics of asthma (inflammation, remodeling, airway hyperreactivity) is the expression of a complex network of molecules, very diverse both within any given patient in time and between any two patients. Some of these networks are repetitive across individuals with asthma and specific for clinical expression, gene–environment interaction and inflammatory cell profiles represent novel endotype-specific diagnostic and therapeutic strategies.
Lippincott Williams & Wilkins