IL-33 drives augmented responses to ozone in obese mice
JA Mathews, N Krishnamoorthy… - Environmental …, 2017 - ehp.niehs.nih.gov
Background: Ozone increases IL-33 in the lungs, and obesity augments the pulmonary
effects of acute ozone exposure. Objectives: We assessed the role of IL-33 in the augmented
effects of ozone observed in obese mice. Methods: Lean wildtype and obese db/db mice
were pretreated with antibodies blocking the IL-33 receptor, ST2, and then exposed to
ozone (2 ppm for 3 hr). Airway responsiveness was assessed, bronchoalveolar lavage
(BAL) was performed, and lung cells harvested for flow cytometry 24 hr later. Effects of …
effects of acute ozone exposure. Objectives: We assessed the role of IL-33 in the augmented
effects of ozone observed in obese mice. Methods: Lean wildtype and obese db/db mice
were pretreated with antibodies blocking the IL-33 receptor, ST2, and then exposed to
ozone (2 ppm for 3 hr). Airway responsiveness was assessed, bronchoalveolar lavage
(BAL) was performed, and lung cells harvested for flow cytometry 24 hr later. Effects of …
