Pathway discovery using transcriptomic profiles in adult-onset severe asthma
PP Hekking, MJ Loza, S Pavlidis, B De Meulder… - Journal of Allergy and …, 2018 - Elsevier
Background Adult-onset severe asthma is characterized by highly symptomatic disease
despite high-intensity asthma treatments. Understanding of the underlying pathways of this
heterogeneous disease is needed for the development of targeted treatments. Gene set
variation analysis is a statistical technique used to identify gene profiles in heterogeneous
samples. Objective We sought to identify gene profiles associated with adult-onset severe
asthma. Methods This was a cross-sectional, observational study in which adult patients with …
despite high-intensity asthma treatments. Understanding of the underlying pathways of this
heterogeneous disease is needed for the development of targeted treatments. Gene set
variation analysis is a statistical technique used to identify gene profiles in heterogeneous
samples. Objective We sought to identify gene profiles associated with adult-onset severe
asthma. Methods This was a cross-sectional, observational study in which adult patients with …