The efficacy of single-high dose inhaled corticosteroid versus oral prednisone treatment on exhaled leukotriene and 8-isoprostane levels in mild to moderate …

O Keskin, U Uluca, M Keskin, B Gogebakan… - Allergologia et …, 2016 - Elsevier
Background The anti-inflammatory effect of high-dose inhaled corticosteroids (ICS) in
children with asthma exacerbation is unknown. We aimed to investigate the efficacy of single-
high dose ICS versus oral prednisone treatment followed by a course of six day high-dose
ICS or oral prednisone (P) treatment on the concentrations of Cys-LTs and 8-isoprostane
levels in the exhaled breath condensate (EBC) of children with asthma exacerbation.
Methods Ninety-four children with moderate–severe asthma exacerbation were evaluated …