Integrative approach identifies corticosteroid response variant in diverse populations with asthma

AM Levin, H Gui, N Hernandez-Pacheco… - Journal of Allergy and …, 2019 - Elsevier
Background Although inhaled corticosteroid (ICS) medication is considered the cornerstone
treatment for patients with persistent asthma, few ICS pharmacogenomic studies have
involved nonwhite populations. Objective We sought to identify genetic predictors of ICS
response in multiple population groups with asthma. Methods The discovery group
comprised African American participants from the Study of Asthma Phenotypes and
Pharmacogenomic Interactions by Race-Ethnicity (SAPPHIRE) who underwent 6 weeks of …