IL-13 polymorphisms contribute to the risk of asthma: a meta-analysis
L Cui, J Jia, CF Ma, SY Li, YP Wang, XM Guo, Q Li… - Clinical …, 2012 - Elsevier
L Cui, J Jia, CF Ma, SY Li, YP Wang, XM Guo, Q Li, HB Yu, WH Liu, LB Gao
Clinical biochemistry, 2012•ElsevierOBJECTIVES: The purpose of this study was to evaluate the effects of interleukin-13 (IL-13)
polymorphisms on the risk of asthma using a meta-analysis. DESIGN AND METHODS:
Fifteen publications were identified by searching Pubmed, Embase, ISI, OVID, and EBSCO
databases. Odds ratios with corresponding 95% confidence intervals were computed to
estimate the association between IL-13 polymorphisms and risk of asthma. RESULTS: The
polymorphisms of R130Q (rs20541) and-1112C/T (rs1800925) in IL-13 gene were …
polymorphisms on the risk of asthma using a meta-analysis. DESIGN AND METHODS:
Fifteen publications were identified by searching Pubmed, Embase, ISI, OVID, and EBSCO
databases. Odds ratios with corresponding 95% confidence intervals were computed to
estimate the association between IL-13 polymorphisms and risk of asthma. RESULTS: The
polymorphisms of R130Q (rs20541) and-1112C/T (rs1800925) in IL-13 gene were …
OBJECTIVES
The purpose of this study was to evaluate the effects of interleukin-13 (IL-13) polymorphisms on the risk of asthma using a meta-analysis.
DESIGN AND METHODS
Fifteen publications were identified by searching Pubmed, Embase, ISI, OVID, and EBSCO databases. Odds ratios with corresponding 95% confidence intervals were computed to estimate the association between IL-13 polymorphisms and risk of asthma.
RESULTS
The polymorphisms of R130Q (rs20541) and -1112C/T (rs1800925) in IL-13 gene were associated with significantly increased risks of asthma in overall analyses. Subgroup analyses showed that the elevated risks occurred in adult-onset asthma, Caucasians, and high quality studies.
CONCLUSIONS
This meta-analysis provides evidence that the R130Q and -1112C/T polymorphisms in IL-13 are risk factors for asthma.
Elsevier