[HTML][HTML] Loss-of-function variants in the filaggrin gene are a significant risk factor for peanut allergy

SJ Brown, Y Asai, HJ Cordell, LE Campbell… - Journal of allergy and …, 2011 - Elsevier
BACKGROUND: IgE-mediated peanut allergy is a complex trait with strong heritability, but its
genetic basis is currently unknown. Loss-of-function mutations within the filaggrin gene are
associated with atopic dermatitis and other atopic diseases; therefore, filaggrin is a
candidate gene in the etiology of peanut allergy. OBJECTIVE: To investigate the association
between filaggrin loss-of-function mutations and peanut allergy. METHODS: Case-control
study of 71 English, Dutch, and Irish oral food challenge–positive patients with peanut …