Mast cells and basophils in allergic inflammation
M Kubo - Current opinion in immunology, 2018 - Elsevier
M Kubo
Current opinion in immunology, 2018•ElsevierHighlights•Mast cells and basophils have similar morphological characteristics and express
the high-affinity FceRI on their cell surface.•Genetically engineered deletion mice
demonstrated some functional differences between mast cells and basophils•Mast cells
controlled IgE-dependent acute allergic responses.•Basophils controlled IgE-mediated
chronic responses, including IgE-mediated chronic allergic inflammation (IgE-
CAI).•Basophils controlled the PAF-mediated IgE-independent anaphylaxis and TSLP …
the high-affinity FceRI on their cell surface.•Genetically engineered deletion mice
demonstrated some functional differences between mast cells and basophils•Mast cells
controlled IgE-dependent acute allergic responses.•Basophils controlled IgE-mediated
chronic responses, including IgE-mediated chronic allergic inflammation (IgE-
CAI).•Basophils controlled the PAF-mediated IgE-independent anaphylaxis and TSLP …
Highlights
- Mast cells and basophils have similar morphological characteristics and express the high-affinity FceRI on their cell surface.
- Genetically engineered deletion mice demonstrated some functional differences between mast cells and basophils
- Mast cells controlled IgE-dependent acute allergic responses.
- Basophils controlled IgE-mediated chronic responses, including IgE-mediated chronic allergic inflammation (IgE-CAI).
- Basophils controlled the PAF-mediated IgE-independent anaphylaxis and TSLP mediated Th2 responses.
- Basophils directly or indirectly controlled Th2 cell differentiation.
- Basophils derived IL-4 controlled activation of group 2 innate lymphoid cells (ILC2s) in TSLP mediated atopic dermatitis and in cysteine protease induced asthmatic responses.
Mast cells and basophils have similar characteristics in terms of their function and development. They both have detrimental functions, being implicated in pro-inflammatory responses to allergens, but can also provide protection against multicellular parasites such as parasitic worms (helminths). Both cell types express the high affinity Fc receptor for IgE, FcεRI, and allergen cross-linking of this receptor triggers degranulation and release a set of cytokines and biochemical mediators. Although mast cells and basophils are similar in many respects, newly developed antibody reagents and genetically modified mouse models that enable cell type-specific deletion have allowed us to appreciate their independent in vivo roles. This review focuses on recent advances in our understanding of the contribution of basophils and mast cells to innate and adaptive allergic responses.
Elsevier