Anti–IL-5 therapy reduces mast cell and IL-9 cell numbers in pediatric patients with eosinophilic esophagitis

IM Otani, AA Anilkumar, RO Newbury, M Bhagat… - Journal of allergy and …, 2013 - Elsevier
BACKGROUND: Eosinophilic esophagitis (EoE) is a clinicopathologic entity of increasing
worldwide prevalence. IL-5 is essential for eosinophil trafficking, and anti–IL-5 therapy
decreases esophageal eosinophilia. EoE is associated with prominent mast cell infiltration.
OBJECTIVE: We investigated whether anti–IL-5 (mepolizumab) treatment reduced
esophageal mast cell accumulation in biopsy specimens from pediatric patients with EoE
from a previous randomized anti–IL-5 trial. METHODS: A subanalysis was completed for …