Retinoic acid receptor–related orphan receptor α–induced activation of adenosine monophosphate–activated protein kinase results in attenuation of hepatic steatosis

EJ Kim, YS Yoon, S Hong, HY Son, TY Na, MH Lee… - Hepatology, 2012 - journals.lww.com
There is increasing evidence that the retinoic acid receptor–related orphan receptor α
(RORα) plays an important role in the regulation of metabolic pathways, particularly of fatty
acid and cholesterol metabolism; however, the role of RORα in the regulation of hepatic
lipogenesis has not been studied. Here, we report that RORα attenuates hepatic steatosis,
probably via activation of the adenosine monophosphate (AMP)-activated protein kinase
(AMPK) and repression of the liver X receptor α (LXRα). First, RORα and its activator …