[HTML][HTML] Bronchial mucosal IFN-α/β and pattern recognition receptor expression in patients with experimental rhinovirus-induced asthma exacerbations
J Zhu, SD Message, P Mallia, T Kebadze… - Journal of Allergy and …, 2019 - Elsevier
Background The innate immune system senses viral infection through pattern recognition
receptors (PRRs), leading to type I interferon production. The role of type I interferon and
PPRs in rhinovirus-induced asthma exacerbations in vivo are uncertain. Objectives We
sought to compare bronchial mucosal type I interferon and PRR expression at baseline and
after rhinovirus infection in atopic asthmatic patients and control subjects. Methods
Immunohistochemistry was used to detect expression of IFN-α, IFN-β, and the PRRs: Toll …
receptors (PRRs), leading to type I interferon production. The role of type I interferon and
PPRs in rhinovirus-induced asthma exacerbations in vivo are uncertain. Objectives We
sought to compare bronchial mucosal type I interferon and PRR expression at baseline and
after rhinovirus infection in atopic asthmatic patients and control subjects. Methods
Immunohistochemistry was used to detect expression of IFN-α, IFN-β, and the PRRs: Toll …