The R576 IL-4 receptor α allele correlates with asthma severity
L Rosa-Rosa, N Zimmermann, JA Bernstein… - Journal of Allergy and …, 1999 - Elsevier
Background: Atopic disorders, including asthma, are very prevalent, affecting up to 40% of
populations, and their incidence is on the rise. Although environmental factors are important
in the development of atopy, there is a strong genetic predisposition. Several genes and
chromosomal regions have been linked to atopy and asthma, supporting the polygenic
nature of these disorders. IL-4 and IL-13 are T H2 cytokines with numerous activities that
contribute to allergic inflammation and asthma. Both IL-4 and IL-13 use the IL-4 receptor α …
populations, and their incidence is on the rise. Although environmental factors are important
in the development of atopy, there is a strong genetic predisposition. Several genes and
chromosomal regions have been linked to atopy and asthma, supporting the polygenic
nature of these disorders. IL-4 and IL-13 are T H2 cytokines with numerous activities that
contribute to allergic inflammation and asthma. Both IL-4 and IL-13 use the IL-4 receptor α …