Exposure to allergen and diesel exhaust particles potentiates secondary allergen-specific memory responses, promoting asthma susceptibility
EB Brandt, JMB Myers, TH Acciani, PH Ryan… - Journal of allergy and …, 2015 - Elsevier
Background Exposure to traffic pollution particulate matter, predominantly diesel exhaust
particles (DEPs), increases the risk of asthma and asthma exacerbation; however, the
underlying mechanisms remain poorly understood. Objective We sought to examine the
effect of DEP exposure on the generation and persistence of allergen-specific memory T
cells in asthmatic patients and translate these findings by determining the effect of early DEP
exposure on the prevalence of allergic asthma in children. Methods The effect of DEPs on …
particles (DEPs), increases the risk of asthma and asthma exacerbation; however, the
underlying mechanisms remain poorly understood. Objective We sought to examine the
effect of DEP exposure on the generation and persistence of allergen-specific memory T
cells in asthmatic patients and translate these findings by determining the effect of early DEP
exposure on the prevalence of allergic asthma in children. Methods The effect of DEPs on …