Intrinsic atopic dermatitis shows similar TH2 and higher TH17 immune activation compared with extrinsic atopic dermatitis
M Suárez-Fariñas, N Dhingra, J Gittler… - Journal of Allergy and …, 2013 - Elsevier
Background Atopic dermatitis (AD) is classified as extrinsic and intrinsic, representing
approximately 80% and 20% of patients with the disease, respectively. Although sharing a
similar clinical phenotype, only extrinsic AD is characterized by high serum IgE levels.
Because most patients with AD exhibit high IgE levels, an “allergic”/IgE-mediated disease
pathogenesis was hypothesized. However, current models associate AD with T-cell
activation, particularly TH 2/TH 22 polarization, and epidermal barrier defects. Objective We …
approximately 80% and 20% of patients with the disease, respectively. Although sharing a
similar clinical phenotype, only extrinsic AD is characterized by high serum IgE levels.
Because most patients with AD exhibit high IgE levels, an “allergic”/IgE-mediated disease
pathogenesis was hypothesized. However, current models associate AD with T-cell
activation, particularly TH 2/TH 22 polarization, and epidermal barrier defects. Objective We …