[HTML][HTML] Filaggrin loss-of-function mutations are associated with enhanced expression of IL-1 cytokines in the stratum corneum of patients with atopic dermatitis and in …
S Kezic, GM O'Regan, R Lutter, I Jakasa… - Journal of allergy and …, 2012 - Elsevier
BACKGROUND: Filaggrin (FLG) mutations result in reduced stratum corneum (SC) natural
moisturizing factor (NMF) components and consequent increased SC pH. Because higher
pH activates SC protease activity, we hypothesized an enhanced release of proinflammatory
IL-1 cytokines from corneocytes in patients with atopic dermatitis (AD) with FLG mutations
(ADFLG) compared with that seen in patients with AD without these mutations (ADNON-
FLG). OBJECTIVES: We sought to investigate SC IL-1 cytokine profiles in the uninvolved …
moisturizing factor (NMF) components and consequent increased SC pH. Because higher
pH activates SC protease activity, we hypothesized an enhanced release of proinflammatory
IL-1 cytokines from corneocytes in patients with atopic dermatitis (AD) with FLG mutations
(ADFLG) compared with that seen in patients with AD without these mutations (ADNON-
FLG). OBJECTIVES: We sought to investigate SC IL-1 cytokine profiles in the uninvolved …
