Defects of filaggrin-like proteins in both lesional and nonlesional atopic skin
L Pellerin, J Henry, CY Hsu, S Balica… - Journal of allergy and …, 2013 - Elsevier
BACKGROUND: Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized
by a disturbed epidermal barrier. In a subset of patients, this is explained by nonsense
mutations in the gene encoding filaggrin (FLG). OBJECTIVES: We sought to evaluate the
respective role of FLG mutations and proinflammatory cytokines and to assess the
expression of FLG, hornerin (HRNR), and FLG2, 2 FLG-like proteins, which are involved in
epidermal barrier functions, in normal skin and both lesional and nonlesional skin of patients …
by a disturbed epidermal barrier. In a subset of patients, this is explained by nonsense
mutations in the gene encoding filaggrin (FLG). OBJECTIVES: We sought to evaluate the
respective role of FLG mutations and proinflammatory cytokines and to assess the
expression of FLG, hornerin (HRNR), and FLG2, 2 FLG-like proteins, which are involved in
epidermal barrier functions, in normal skin and both lesional and nonlesional skin of patients …