Background Atopic dermatitis (AD) is a common skin disease characterized by recurrent
episodes of itching. Genetic variation associated with the persistence of AD has not been
described for African American subjects. Objective We sought to evaluate genetic variation
of filaggrin-2 (FLG2) in African American subjects with AD. Methods We evaluated a
multiyear prospective cohort study of African American children with AD with respect to FLG2
variation based on whole-exome sequencing, followed by a targeted analysis. We ultimately …