The immunology of atopic dermatitis and its reversibility with broad-spectrum and targeted therapies

PM Brunner, E Guttman-Yassky, DYM Leung - Journal of Allergy and …, 2017 - Elsevier
Atopic dermatitis (AD), the most common chronic inflammatory skin disease, is driven by
both terminal keratinocyte differentiation defects and strong type 2 immune responses. In
contrast to chronic plaque-type psoriasis, AD is now understood to be a much more
heterogeneous disease, with additional activation of TH 22, TH 17/IL-23, and TH 1 cytokine
pathways depending on the subtype of the disease. In this review we discuss our current
understanding of the AD immune map in both patients with early-onset and those with …