Minimally invasive skin tape strip RNA sequencing identifies novel characteristics of the type 2–high atopic dermatitis disease endotype
N Dyjack, E Goleva, C Rios, BE Kim, L Bin… - Journal of Allergy and …, 2018 - Elsevier
Background Expression profiling of skin biopsy specimens has established molecular
features of the skin in patients with atopic dermatitis (AD). The invasiveness of biopsies has
prevented their use in defining individual-level AD pathobiological mechanisms (endotypes)
in large research studies. Objective We sought to determine whether minimally invasive skin
tape strip transcriptome analysis identifies gene expression dysregulation in AD and
molecular disease endotypes. Methods We sampled nonlesional and lesional skin tape …
features of the skin in patients with atopic dermatitis (AD). The invasiveness of biopsies has
prevented their use in defining individual-level AD pathobiological mechanisms (endotypes)
in large research studies. Objective We sought to determine whether minimally invasive skin
tape strip transcriptome analysis identifies gene expression dysregulation in AD and
molecular disease endotypes. Methods We sampled nonlesional and lesional skin tape …