Eosinophilic esophagitis: epithelial mesenchymal transition contributes to esophageal remodeling and reverses with treatment
AF Kagalwalla, N Akhtar, SA Woodruff, BA Rea… - Journal of Allergy and …, 2012 - Elsevier
BACKGROUND: Mechanisms underlying esophageal remodeling with subepithelial fibrosis
in subjects with eosinophilic esophagitis (EoE) have not been delineated. OBJECTIVES: We
sought to explore a role for epithelial mesenchymal transition (EMT) in subjects with EoE
and determine whether EMT resolves with treatment. METHODS: Esophageal biopsy
specimens from 60 children were immunostained for epithelial (cytokeratin) and
mesenchymal (vimentin) EMT biomarkers, and EMT was quantified. Subjects studied had …
in subjects with eosinophilic esophagitis (EoE) have not been delineated. OBJECTIVES: We
sought to explore a role for epithelial mesenchymal transition (EMT) in subjects with EoE
and determine whether EMT resolves with treatment. METHODS: Esophageal biopsy
specimens from 60 children were immunostained for epithelial (cytokeratin) and
mesenchymal (vimentin) EMT biomarkers, and EMT was quantified. Subjects studied had …
