Downregulation of glutathione S-transferase pi in asthma contributes to enhanced oxidative stress
KT Schroer, AM Gibson, U Sivaprasad, SA Bass… - Journal of Allergy and …, 2011 - Elsevier
BACKGROUND: Glutathione S-transferase pi (GSTPi) is the predominant redox regulator in
the lung. Although evidence implicates an important role for GSTPi in asthma, the
mechanism for this has remained elusive. OBJECTIVES: We sought to determine how
GSTPi is regulated in asthma and to elucidate its role in maintaining redox homeostasis.
METHODS: We elucidated the regulation of GSTPi in children with asthma and used murine
models of asthma to determine the role of GSTPi in redox homeostasis. RESULTS: Our …
the lung. Although evidence implicates an important role for GSTPi in asthma, the
mechanism for this has remained elusive. OBJECTIVES: We sought to determine how
GSTPi is regulated in asthma and to elucidate its role in maintaining redox homeostasis.
METHODS: We elucidated the regulation of GSTPi in children with asthma and used murine
models of asthma to determine the role of GSTPi in redox homeostasis. RESULTS: Our …