BACKGROUND: Colonization of the skin by Staphylococcus aureus in individuals with
atopic dermatitis exacerbates inflammation. Atopic dermatitis is associated with loss-of-
function mutations in the filaggrin (FLG) gene, accompanied by reduced levels of filaggrin
breakdown products on the skin. OBJECTIVE: To assess the affect of growth in the presence
of the filaggrin breakdown products urocanic acid (UCA) and pyrrolidone carboxylic acid
(PCA) on fitness of and protein expression by S aureus. METHODS: S aureus was grown for …