[HTML][HTML] Skin colonization by Staphylococcus aureus precedes the clinical diagnosis of atopic dermatitis in infancy

P Meylan, C Lang, S Mermoud, A Johannsen… - Journal of Investigative …, 2017 - Elsevier
P Meylan, C Lang, S Mermoud, A Johannsen, S Norrenberg, D Hohl, Y Vial, G Prod'Hom…
Journal of Investigative Dermatology, 2017Elsevier
Atopic dermatitis (AD) has a well-established association with skin colonization or infection
by Staphylococcus aureus, which can exacerbate the disease. However, a causal
relationship between specific changes in skin colonization during the first years of life and
AD development still remains unclear. In this prospective birth cohort study, we aimed to
characterize the association between skin colonization and AD development in 149 white
infants with or without a family history of atopy. We assessed infants clinically and collected …
Atopic dermatitis (AD) has a well-established association with skin colonization or infection by Staphylococcus aureus, which can exacerbate the disease. However, a causal relationship between specific changes in skin colonization during the first years of life and AD development still remains unclear. In this prospective birth cohort study, we aimed to characterize the association between skin colonization and AD development in 149 white infants with or without a family history of atopy. We assessed infants clinically and collected axillary and antecubital fossa skin swabs for culture-based analysis at birth and at seven time points over the first 2 years of life. We found that at age 3 months, S. aureus was more prevalent on the skin of infants who developed AD later on. S. aureus prevalence was increased on infants’ skin at the time of AD onset and also 2 months before it, when compared with age-matched, unaffected infants. Furthermore, at AD onset, infants testing positive for S. aureus were younger than uncolonized subjects. In conclusion, our results suggest that specific changes in early-life skin colonization may actively contribute to clinical AD onset in infancy.
Elsevier