Blocking IL-25 prevents airway hyperresponsiveness in allergic asthma
SJ Ballantyne, JL Barlow, HE Jolin, P Nath… - Journal of Allergy and …, 2007 - Elsevier
BACKGROUND: IL-25 (IL-17E), a member of the IL-17 family of immunoregulatory cytokines,
has been implicated in the regulation of type 2 immunity. Its roles in antigen-driven airway
inflammation and airway hyperresponsiveness (AHR) remain to be fully established.
OBJECTIVE: We sought to determine whether a neutralizing antibody against IL-25
represents a novel therapeutic for airway inflammation and hyperresponsiveness.
METHODS: We generated a neutralizing mAb against IL-25 and used this to inhibit IL-25 in …
has been implicated in the regulation of type 2 immunity. Its roles in antigen-driven airway
inflammation and airway hyperresponsiveness (AHR) remain to be fully established.
OBJECTIVE: We sought to determine whether a neutralizing antibody against IL-25
represents a novel therapeutic for airway inflammation and hyperresponsiveness.
METHODS: We generated a neutralizing mAb against IL-25 and used this to inhibit IL-25 in …