TH9 cells are required for tissue mast cell accumulation during allergic inflammation

S Sehra, W Yao, ET Nguyen, NL Glosson-Byers… - Journal of Allergy and …, 2015 - Elsevier
Background IL-9 is important for the growth and survival of mast cells. IL-9 is produced by T
cells, natural killer T cells, mast cells, eosinophils, and innate lymphoid cells, although the
cells required for mast cell accumulation during allergic inflammation remain undefined.
Objective We sought to elucidate the role of TH 9 cells in promoting mast cell accumulation
in models of allergic lung inflammation. Methods Adoptive transfer of ovalbumin-specific TH
2 and TH 9 cells was used to assess the ability of each subset to mediate mast cell …