Anti–IL-5 (mepolizumab) therapy for eosinophilic esophagitis
ML Stein, MH Collins, JM Villanueva… - Journal of Allergy and …, 2006 - Elsevier
BACKGROUND: Eosinophilic esophagitis (EE) is characterized by high numbers of
eosinophils in the esophagus and epithelial hyperplasia, and is being increasingly
recognized. IL-5 promotes eosinophil trafficking to the esophagus, and positively regulates
eosinophil growth, activation, survival, and tissue recruitment. OBJECTIVE: We
hypothesized that the humanized monoclonal IgG1 antibody against human IL-5
(mepolizumab) may be useful in the control of EE. METHODS: An open-label phase I/II …
eosinophils in the esophagus and epithelial hyperplasia, and is being increasingly
recognized. IL-5 promotes eosinophil trafficking to the esophagus, and positively regulates
eosinophil growth, activation, survival, and tissue recruitment. OBJECTIVE: We
hypothesized that the humanized monoclonal IgG1 antibody against human IL-5
(mepolizumab) may be useful in the control of EE. METHODS: An open-label phase I/II …