Effect of subcutaneous dupilumab on nasal polyp burden in patients with chronic sinusitis and nasal polyposis: a randomized clinical trial
C Bachert, L Mannent, RM Naclerio, J Mullol… - Jama, 2016 - jamanetwork.com
Importance Dupilumab has demonstrated efficacy in patients with asthma and atopic
dermatitis, which are both type 2 helper T-cell–mediated diseases. Objective To assess
inhibition of interleukins 4 and 13 with dupilumab in patients with chronic sinusitis and nasal
polyposis. Design, Setting, and Participants A randomized, double-blind, placebo-controlled
parallel-group study conducted at 13 sites in the United States and Europe between August
2013 and August 2014 in 60 adults with chronic sinusitis and nasal polyposis refractory to …
dermatitis, which are both type 2 helper T-cell–mediated diseases. Objective To assess
inhibition of interleukins 4 and 13 with dupilumab in patients with chronic sinusitis and nasal
polyposis. Design, Setting, and Participants A randomized, double-blind, placebo-controlled
parallel-group study conducted at 13 sites in the United States and Europe between August
2013 and August 2014 in 60 adults with chronic sinusitis and nasal polyposis refractory to …