[HTML][HTML] Lifelong memory responses perpetuate humoral TH2 immunity and anaphylaxis in food allergy

R Jiménez-Saiz, DK Chu, TS Mandur, TD Walker… - Journal of Allergy and …, 2017 - Elsevier
Background A number of food allergies (eg, fish, shellfish, and nuts) are lifelong, without any
disease-transforming therapies, and unclear in their underlying immunology. Clinical
manifestations of food allergy are largely mediated by IgE. Although persistent IgE titers
have been attributed conventionally to long-lived IgE+ plasma cells (PCs), this has not been
directly and comprehensively tested. Objective We sought to evaluate mechanisms
underlying persistent IgE and allergic responses to food allergens. Methods We used a …