Treatment of childhood asthma with anti-immunoglobulin E antibody (omalizumab)
H Milgrom, W Berger, A Nayak, N Gupta, S Pollard… - …, 2001 - publications.aap.org
Background and Objective. There seems to be a strong causal relationship between allergy
and the origins of asthma. Susceptibility to both is determined by a combination of genetics
and environment acting through a complex network of cytokines. Nearly 90% of affected
children have positive skin tests indicating the presence of specific immunoglobulin E (IgE),
with sensitivity to house dust mite, Alternaria, cockroach, cat, and dog most closely linked to
the disease. Greater exposure to house dust mite during infancy leads to earlier onset of …
and the origins of asthma. Susceptibility to both is determined by a combination of genetics
and environment acting through a complex network of cytokines. Nearly 90% of affected
children have positive skin tests indicating the presence of specific immunoglobulin E (IgE),
with sensitivity to house dust mite, Alternaria, cockroach, cat, and dog most closely linked to
the disease. Greater exposure to house dust mite during infancy leads to earlier onset of …