Autocrine PDGF stimulation in malignancies

CH Heldin - Upsala journal of medical sciences, 2012 - Taylor & Francis
CH Heldin
Upsala journal of medical sciences, 2012Taylor & Francis
Platelet-derived growth factor (PDGF) isoforms are important mitogens for different types of
mesenchymal cells, which have important functions during the embryonal development and
in the adult during wound healing and tissue homeostasis. In tumors, PDGF isoforms are
often over-expressed and contribute to the growth of both normal and malignant cells. This
review focuses on tumors expressing PDGF isoforms together with their tyrosine kinase
receptors, thus resulting in autocrine stimulation of growth and survival. Patients with such …
Abstract
Platelet-derived growth factor (PDGF) isoforms are important mitogens for different types of mesenchymal cells, which have important functions during the embryonal development and in the adult during wound healing and tissue homeostasis. In tumors, PDGF isoforms are often over-expressed and contribute to the growth of both normal and malignant cells. This review focuses on tumors expressing PDGF isoforms together with their tyrosine kinase receptors, thus resulting in autocrine stimulation of growth and survival. Patients with such tumors could benefit from treatment with inhibitors of either PDGF or PDGF receptors.
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