Emerging roles for hyaluronidase in cancer metastasis and therapy
CO McAtee, JJ Barycki, MA Simpson - Advances in cancer research, 2014 - Elsevier
Hyaluronidases are a family of five human enzymes that have been differentially implicated
in the progression of many solid tumor types, both clinically and in functional studies.
Advances in the past 5 years have clarified many apparent contradictions:(1) by
demonstrating that specific hyaluronidases have alternative substrates to hyaluronan (HA)
or do not exhibit any enzymatic activity,(2) that high-molecular weight HA polymers elicit
signaling effects that are opposite those of the hyaluronidase-digested HA oligomers, and …
in the progression of many solid tumor types, both clinically and in functional studies.
Advances in the past 5 years have clarified many apparent contradictions:(1) by
demonstrating that specific hyaluronidases have alternative substrates to hyaluronan (HA)
or do not exhibit any enzymatic activity,(2) that high-molecular weight HA polymers elicit
signaling effects that are opposite those of the hyaluronidase-digested HA oligomers, and …