The combination of NK and CD8+ T cells with CCL20/IL15-armed oncolytic adenoviruses enhances the growth suppression of TERT-positive tumor cells
J Ye, W Qi, M Liu, Y Li - Cellular immunology, 2017 - Elsevier
Adoptive immunotherapy and targeted gene therapy have been extensively used to
eliminate tumor cells. The combination treatment is capable of efficiently generating an
effective antitumor immune response and disrupting tumor-induced tolerance. Moreover,
effective antitumor immune responses are dependent on coordinate interaction among
various effector cells. This study focused on whether the combination of cytotoxic effector cell-
based adoptive immunotherapy and CCL20/IL15-armed oncolytic adenoviruses could …
eliminate tumor cells. The combination treatment is capable of efficiently generating an
effective antitumor immune response and disrupting tumor-induced tolerance. Moreover,
effective antitumor immune responses are dependent on coordinate interaction among
various effector cells. This study focused on whether the combination of cytotoxic effector cell-
based adoptive immunotherapy and CCL20/IL15-armed oncolytic adenoviruses could …