Differences in innate immune function between allergic and nonallergic children: new insights into immune ontogeny

MK Tulic, M Hodder, A Forsberg, S McCarthy… - Journal of Allergy and …, 2011 - Elsevier
BACKGROUND: Microbial products are of central interest in the modulation of allergic
propensity. OBJECTIVE: We sought to explore whether allergic children show differences in
microbial Toll-like receptor (TLR)–mediated responses over their first 5 years of life.
METHODS: Mononuclear cells isolated from 35 allergic and 35 nonallergic children at birth
and 1, 2.5, and 5 years of age were stimulated with TLR2-TLR9 ligands to study innate
immune function and with allergens or mitogen to assess adaptive T-cell responses …