Atopic dermatitis: pathophysiology

W David Boothe, JA Tarbox, MB Tarbox - Management of atopic dermatitis …, 2017 - Springer
The pathophysiology of atopic dermatitis is complex and multifactorial, involving elements of
barrier dysfunction, alterations in cell mediated immune responses, IgE mediated
hypersensitivity, and environmental factors. Loss of function mutations in filaggrin have been
implicated in severe atopic dermatitis due to a potential increase in trans-epidermal water
loss, pH alterations, and dehydration. Other genetic changes have also been identified
which may alter the skin's barrier function, resulting in an atopic dermatitis phenotype. The …

[HTML][HTML] Atopic dermatitis: natural history, diagnosis, and treatment

SF Thomsen - International Scholarly Research Notices, 2014 - hindawi.com
Atopic dermatitis is an inflammatory skin disease with early onset and with a lifetime
prevalence of approximately 20%. The aetiology of atopic dermatitis is unknown, but the
recent discovery of filaggrin mutations holds promise that the progression of atopic
dermatitis to asthma in later childhood may be halted. Atopic dermatitis is not always easily
manageable and every physician should be familiar with the fundamental aspects of
treatment. This paper gives an overview of the natural history, clinical features, and …