Leukotrienes are pro-inflammatory lipid mediators, which are biosynthesized via the
lipoxygenase pathway of the arachidonic acid cascade. Lipoxygenases form a family of lipid
peroxidizing enzymes and human lipoxygenase isoforms have been implicated in the
pathogenesis of inflammatory, hyperproliferative (cancer) and neurodegenerative diseases.
Lipoxygenases are not restricted to humans but also occur in a large number of pro-and
eucaryotic organisms. Lipoxygenase-like sequences have been identified in the three …