Experimental asthma persists in IL-33 receptor knockout mice because of the emergence of thymic stromal lymphopoietin–driven IL-9+ and IL-13+ type 2 innate …

M Verma, S Liu, L Michalec, A Sripada… - Journal of Allergy and …, 2018 - Elsevier
Background IL-33 plays an important role in the development of experimental asthma.
Objective We sought to study the role of the IL-33 receptor suppressor of tumorigenicity 2
(ST2) in the persistence of asthma in a mouse model. Methods We studied allergen-induced
experimental asthma in ST2 knockout (KO) and wild-type control mice. We measured airway
hyperresponsiveness by using flexiVent; inflammatory indices by using ELISA, histology,
and real-time PCR; and type 2 innate lymphoid cells (ILC2s) in lung single-cell preparations …