Mechanisms underlying induction of tolerance to foods
MC Berin, WG Shreffler - Immunology and Allergy …, 2016 - immunology.theclinics.com
An early description of the phenomenon of oral tolerance was provided by Wells and
Osborne in 1911, when they described a series of studies showing that guinea pigs could
not be induced to undergo experimental anaphylaxis to corn or oats if it was a component of
the diet. 1 In the intervening century, there has been a growing body of literature defining the
immune mechanisms of oral tolerance. Classic oral tolerance experiments are performed by
feeding of antigen, either a single high-dose Disclosure: The authors have no conflicts of …
Osborne in 1911, when they described a series of studies showing that guinea pigs could
not be induced to undergo experimental anaphylaxis to corn or oats if it was a component of
the diet. 1 In the intervening century, there has been a growing body of literature defining the
immune mechanisms of oral tolerance. Classic oral tolerance experiments are performed by
feeding of antigen, either a single high-dose Disclosure: The authors have no conflicts of …