Filaggrin loss-of-function mutations are associated with food allergy in childhood and adolescence
D Venkataraman, N Soto-Ramírez… - Journal of Allergy and …, 2014 - Elsevier
Background Filaggrin is an epidermal protein that has a role in skin barrier function.
Filaggrin loss-of-function (FLG-LOF) mutations are a significant risk factor for eczema and
atopy, but their association with food allergy (FA) is less clear. Objective We explored the
longitudinal relationship between 3 common FLG-LOF mutations and FA using the Isle of
Wight birth cohort. Methods FA diagnosis was based on recognized allergic reactions within
4 hours after exposure to known food allergens. Food allergen sensitization (FAS) was …
Filaggrin loss-of-function (FLG-LOF) mutations are a significant risk factor for eczema and
atopy, but their association with food allergy (FA) is less clear. Objective We explored the
longitudinal relationship between 3 common FLG-LOF mutations and FA using the Isle of
Wight birth cohort. Methods FA diagnosis was based on recognized allergic reactions within
4 hours after exposure to known food allergens. Food allergen sensitization (FAS) was …