Allergen-specific T cells in IgE-mediated food allergy
A Saidova, AM Hershkop, M Ponce… - Archivum immunologiae et …, 2018 - Springer
A Saidova, AM Hershkop, M Ponce, T Eiwegger
Archivum immunologiae et therapiae experimentalis, 2018•SpringerFood allergy is the major reason for severe anaphylaxis in childhood and adolescence.
Currently, effective and safe treatments for food allergy are unavailable. Allergen-specific
CD4+ T cells have a pivotal role in causing and maintaining the allergic response to food
allergens. The purpose of this review is to provide an overview on the role of allergen-
specific T cells in food allergy during allergic sensitization, natural tolerance development
and allergen immunotherapy. Allergen-specific T cells in the context of food allergy are …
Currently, effective and safe treatments for food allergy are unavailable. Allergen-specific
CD4+ T cells have a pivotal role in causing and maintaining the allergic response to food
allergens. The purpose of this review is to provide an overview on the role of allergen-
specific T cells in food allergy during allergic sensitization, natural tolerance development
and allergen immunotherapy. Allergen-specific T cells in the context of food allergy are …
Abstract
Food allergy is the major reason for severe anaphylaxis in childhood and adolescence. Currently, effective and safe treatments for food allergy are unavailable. Allergen-specific CD4+ T cells have a pivotal role in causing and maintaining the allergic response to food allergens. The purpose of this review is to provide an overview on the role of allergen-specific T cells in food allergy during allergic sensitization, natural tolerance development and allergen immunotherapy. Allergen-specific T cells in the context of food allergy are predominantly of a Th2 type with slightly different surface marker expression patterns in different food allergies. During the process of reverting food allergy to a status of tolerance or sustained unresponsiveness there is a loss of this Th2 committed compartment with an asymptotic approximation to a regulatory and Th0/Th1 dominated compartment seen in non-allergic individuals. This process is accompanied by a significant reduction of absolute frequencies of allergen-specific T cells. Particularly, regulatory T cells may provide significant help to achieve sustained control of the effector cell populations via suppression of effector cell function and possibly induction of blocking antibodies.
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