Modulation of neuronal excitability by immune mediators in epilepsy
V Iori, F Frigerio, A Vezzani - Current opinion in pharmacology, 2016 - Elsevier
Highlights•Inflammatory molecules have neuromodulatory effects distinct from their immune
functions.•Inflammatory molecules contribute to neuronal hyperexcitability underlying
seizures.•Inhibition of specific inflammatory signals reduces seizures and epileptogenesis.A
complex set of inflammatory molecules and their receptors has been described in
epileptogenic foci in different forms of pharmacoresistant epilepsies. By activating receptor-
mediated pathways in neurons, these molecules have profound neuromodulatory effects …
functions.•Inflammatory molecules contribute to neuronal hyperexcitability underlying
seizures.•Inhibition of specific inflammatory signals reduces seizures and epileptogenesis.A
complex set of inflammatory molecules and their receptors has been described in
epileptogenic foci in different forms of pharmacoresistant epilepsies. By activating receptor-
mediated pathways in neurons, these molecules have profound neuromodulatory effects …