Epileptogenesis and enhanced prepulse inhibition in GABAB1-deficient mice
HM Prosser, CH Gill, WD Hirst, E Grau… - Molecular and Cellular …, 2001 - Elsevier
The recent cloning of two GABAB receptor subunits, GABAB1 and GABAB2, has raised the
possibility that differences in GABAB receptor subunit composition may give rise to
pharmacologically or functionally distinct receptors. If present, such molecular diversity could
permit the selective targeting of GABAB receptor subtypes specifically involved in
pathologies such as drug addiction, spasticity, pain, and epilepsy. To address these issues
we have developed a GABAB1 subunit knockout mouse using gene targeting techniques. In …
possibility that differences in GABAB receptor subunit composition may give rise to
pharmacologically or functionally distinct receptors. If present, such molecular diversity could
permit the selective targeting of GABAB receptor subtypes specifically involved in
pathologies such as drug addiction, spasticity, pain, and epilepsy. To address these issues
we have developed a GABAB1 subunit knockout mouse using gene targeting techniques. In …