Cellular strategies of axonal pathfinding
J Raper, C Mason - Cold Spring Harbor perspectives in …, 2010 - cshperspectives.cshlp.org
J Raper, C Mason
Cold Spring Harbor perspectives in biology, 2010•cshperspectives.cshlp.orgAxons follow highly stereotyped and reproducible trajectories to their targets. In this review
we address the properties of the first pioneer neurons to grow in the developing nervous
system and what has been learned over the past several decades about the extracellular
and cell surface substrata on which axons grow. We then discuss the types of guidance cues
and their receptors that influence axon extension, what determines where cues are
expressed, and how axons respond to the cues they encounter in their environment.
we address the properties of the first pioneer neurons to grow in the developing nervous
system and what has been learned over the past several decades about the extracellular
and cell surface substrata on which axons grow. We then discuss the types of guidance cues
and their receptors that influence axon extension, what determines where cues are
expressed, and how axons respond to the cues they encounter in their environment.
Axons follow highly stereotyped and reproducible trajectories to their targets. In this review we address the properties of the first pioneer neurons to grow in the developing nervous system and what has been learned over the past several decades about the extracellular and cell surface substrata on which axons grow. We then discuss the types of guidance cues and their receptors that influence axon extension, what determines where cues are expressed, and how axons respond to the cues they encounter in their environment.
cshperspectives.cshlp.org