Nerve growth factor contributes to the generation of inflammatory sensory hypersensitivity
Neuroscience, 1994•Elsevier
Experimental inflammation produced by an intraplantar injection of complete Freund's
adjuvant results in local sensory hypersensitivity and up-regulates the neuropeptides
substance P and calcitonin gene related peptide in the primary sensory neurons innervating
the inflamed tissue. The inflammation also elevates nerve growth factor levels in the skin.
Systemic administration of anti-NGF neutralizing antibodies prevent the behavioral
sensitivity, the up-regulation of neuropeptides and the inflammation-induced expression of …
adjuvant results in local sensory hypersensitivity and up-regulates the neuropeptides
substance P and calcitonin gene related peptide in the primary sensory neurons innervating
the inflamed tissue. The inflammation also elevates nerve growth factor levels in the skin.
Systemic administration of anti-NGF neutralizing antibodies prevent the behavioral
sensitivity, the up-regulation of neuropeptides and the inflammation-induced expression of …
Abstract
Experimental inflammation produced by an intraplantar injection of complete Freund's adjuvant results in local sensory hypersensitivity and up-regulates the neuropeptides substance P and calcitonin gene related peptide in the primary sensory neurons innervating the inflamed tissue. The inflammation also elevates nerve growth factor levels in the skin. Systemic administration of anti-NGF neutralizing antibodies prevent the behavioral sensitivity, the up-regulation of neuropeptides and the inflammation-induced expression of the immediate early gene c-fos in dorsal horn neurons, without modifying swelling and erythema. Elevation of the neurotrophin NGF in the periphery is a major contributor, therefore, of inflammatory pain.
Elsevier