Lsc is required for marginal zone B cells, regulation of lymphocyte motility and immune responses

I Girkontaite, K Missy, V Sakk, A Harenberg… - Nature …, 2001 - nature.com
I Girkontaite, K Missy, V Sakk, A Harenberg, K Tedford, T Pötzel, K Pfeffer, KD Fischer
Nature immunology, 2001nature.com
Lsc (the murine homolog of human p115 Rho GEF) is a member of the Dbl-homology family
of GTP exchange factors and is a specific activator of Rho. Lsc is activated by the Gα13
subunit of heterotrimeric G proteins and contains a regulator of G protein signaling domain
that downmodulates Gα12 and Gα13. Lsc is expressed primarily in the hematopoietic
system and links the activation of Gα12 and Gα13–coupled receptors to actin polymerization
in B and T cells. Lsc is essential for marginal zone B (MZB) cell homeostasis and for the …
Abstract
Lsc (the murine homolog of human p115 Rho GEF) is a member of the Dbl-homology family of GTP exchange factors and is a specific activator of Rho. Lsc is activated by the Gα13 subunit of heterotrimeric G proteins and contains a regulator of G protein signaling domain that downmodulates Gα12 and Gα13. Lsc is expressed primarily in the hematopoietic system and links the activation of Gα12 and Gα13–coupled receptors to actin polymerization in B and T cells. Lsc is essential for marginal zone B (MZB) cell homeostasis and for the generation of immune responses. Although Lsc-deficient lymphocytes show reduced basal motility, MZB cells show enhanced migration after serum activation. Thus, Lsc is a critical regulator of MZB cells and immune functions.
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