[HTML][HTML] The Gα13-Rho signaling axis is required for SDF-1-induced migration through CXCR4
W Tan, D Martin, JS Gutkind - Journal of Biological Chemistry, 2006 - ASBMB
The CXC chemokine stromal cell-derived factor-1α (SDF-1) binds to CXCR4, a seven-
transmembrane G protein-coupled receptor that plays a critical role in many physiological
processes that involve cell migration and cell fate decisions, ranging from stem cell homing,
angiogenesis, and neuronal development to immune cell trafficking. CXCR4 is also
implicated in various pathological conditions, including metastatic spread and human
immunodeficiency virus infection. Although SDF-1-induced cell migration in CXCR4 …
transmembrane G protein-coupled receptor that plays a critical role in many physiological
processes that involve cell migration and cell fate decisions, ranging from stem cell homing,
angiogenesis, and neuronal development to immune cell trafficking. CXCR4 is also
implicated in various pathological conditions, including metastatic spread and human
immunodeficiency virus infection. Although SDF-1-induced cell migration in CXCR4 …