How to make a heart: the origin and regulation of cardiac progenitor cells
SD Vincent, ME Buckingham - Current topics in developmental biology, 2010 - Elsevier
The formation of the heart is a complex morphogenetic process that depends on the
spatiotemporally regulated contribution of cardiac progenitor cells. These mainly derive from
the splanchnic mesoderm of the first and second heart field (SHF), with an additional
contribution of neurectodermally derived neural crest cells that are critical for the maturation
of the arterial pole of the heart. The origin and distinguishing characteristics of the two heart
fields, as well as the relation of the SHF to the proepicardial organ and to a proposed third …
spatiotemporally regulated contribution of cardiac progenitor cells. These mainly derive from
the splanchnic mesoderm of the first and second heart field (SHF), with an additional
contribution of neurectodermally derived neural crest cells that are critical for the maturation
of the arterial pole of the heart. The origin and distinguishing characteristics of the two heart
fields, as well as the relation of the SHF to the proepicardial organ and to a proposed third …
